Data/hora: 04/06/2024 02:20:45

Provedor de dados: | 74
País: | Brazil
Título: | Protective effect of carboxymethyl-glucan (CM-G) against DNA damage in patients with advanced prostate cancer
Autores: | Magnani,Marciane; Castro-Gomez,Raul Jorge Hernan; Mori,Mateus Prates; Kuasne,Hellen; Gregório,Emerson Pereira; Libos Jr,Farid; Cólus,Ilce Mara de Syllos.
Data: | 2011-01-01
Ano: | 2011
Palavras-chave: | Antioxidant; Β-D-glucan; Carboxymethyl-glucan; Prostate cancer.
Resumo: | Carboxymethyl-glucan (CM-G) is a soluble derivative from Saccharomyces cerevisiae (1 → 3)(1 → 6)-β-D-glucan. The protective efficiency of CM-G against DNA damage in cells from patients with advanced prostate cancer (PCa), and undergoing Androgen Deprivation Therapy (ADT), was evaluated. DNA damage scores were obtained by the comet assay, both before and after treatment with CM-G. The reduction in DNA damage, ranging from 18% to 87%, with an average of 59%, was not related to the increased number of leukocytes in peripheral blood. The results demonstrate for the first time the protective effect of CM-G against DNA damage in patients with advanced PCa. Among smokers, three presented the highest reduction in DNA damage after treatment with CM-G. There was no observable relationship between DNA damage scores before and after treatment, and age, alcoholism and radiotherapy.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100023
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572010005000103
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.34 n.1 2011
Fonte: | info:eu-repo/semantics/openAccess