Data/hora: 11/06/2024 12:07:16

Provedor de dados: | 74
País: | Brazil
Título: | microRNAs and the mammary gland: a new understanding of gene expression
Autores: | Gigli,Isabel; Maizon,Daniel Omar.
Data: | 2013-01-01
Ano: | 2013
Palavras-chave: | Lactation; Mastitis; Milk; MiRNA.
Resumo: | MicroRNAs (miRNAs) have been identified in cells as well as in exosomes in biological fluids such as milk. In mammary gland, most of the miRNAs studied have functions related to immunity and show alterations in their pattern of expression during lactation. In mastitis, the inflammatory response caused by Streptococcus uberis alters the expression of miRNAs that may regulate the innate immune system. These small RNAs are stable at room temperature and are resistant to repeated freeze/thaw cycles, acidic conditions and degradation by RNAse, making them resistant to industrial procedures. These properties mean that miRNAs could have multiple applications in veterinary medicine and biotechnology. Indeed, lactoglobulin-free milk has been produced in transgenic cows expressing specific miRNAs. Although plant and animal miRNAs have undergone independent evolutionary adaptation recent studies have demonstrated a cross-kingdom passage in which rice miRNA was isolated from human serum. This finding raises questions about the possible effect that miRNAs present in foods consumed by humans could have on human gene regulation. Further studies are needed before applying miRNA biotechnology to the milk industry. New discoveries and a greater knowledge of gene expression will lead to a better understanding of the role of miRNAs in physiology, nutrition and evolution.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000400001
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572013005000040
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.36 n.4 2013
Fonte: | info:eu-repo/semantics/openAccess