Data/hora: 09/06/2024 07:24:17

Provedor de dados: | 74
País: | Brazil
Título: | Glutathione S-transferase Mu (GSTM1) null genotype in relation to gender, age and smoking status in a healthy Brazilian population
Autores: | Losi-Guembarovski,Roberta; D’Arce,Luciana Paula Grégio; Cólus,Ilce Mara de Syllos.
Data: | 2002-01-01
Ano: | 2002
Palavras-chave: | Glutathione S-transferase Mu (GSTM1); Control individuals; Brazilian population; Age; Smoking habit.
Resumo: | The glutathione S-transferase mu (GSTM1) gene which acts during phase II of xenobiotic metabolism is polymorphic in the population, being absent in about 30-50% of individuals depending on the ethnic group from which they come. Epidemiological studies suggest that individuals who are homozygous null at the GSTM1 locus may have an increased risk of developing various types of neoplastic disease. We used the polymerase chain reaction (PCR) to estimate the frequency of GSTM1 in 176 healthy individuals from the north of Paraná (Brazilian state), the null genotype being detected in 48.86% of these individuals. The Student’s t-test was used to evaluate the frequency of the glutathione S-transferase null genotype in relation to age, gender and smoking habit and no significant differences were found. In our sample there were 142 individuals of Caucasian origin, of which 47.88% had the null genotype. When applied to the Caucasian group only (n = 142) the Student’s t-test again showed no significant differences between the frequency of the GSTM1 null genotype and age, gender and smoking habit.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000400001
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572002000400001
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.25 n.4 2002
Fonte: | info:eu-repo/semantics/openAccess