Data/hora: 10/06/2024 07:45:28

Provedor de dados: | 74
País: | Brazil
Título: | Identification of candidate genes for lung cancer somatic mutation test kits
Autores: | Chen,Yong; Shi,Jian-Xin; Pan,Xu-Feng; Feng,Jian; Zhao,Heng.
Data: | 2013-01-01
Ano: | 2013
Palavras-chave: | Lung cancer; Next-generation sequencing; Somatic mutation kit; COSMIC.
Resumo: | Over the past three decades, mortality from lung cancer has sharply and continuously increased in China, ascending to the first cause of death among all types of cancer. The ability to identify the actual sequence of gene mutations may help doctors determine which mutations lead to precancerous lesions and which produce invasive carcinomas, especially using next-generation sequencing (NGS) technology. In this study, we analyzed the latest lung cancer data in the COSMIC database, in order to find genomic "hotspots" that are frequently mutated in human lung cancer genomes. The results revealed that the most frequently mutated lung cancer genes are EGFR, KRAS and TP53.In recent years, EGFR and KRAS lung cancer test kits have been utilized for detecting lung cancer patients, but they presented many disadvantages, as they proved to be of low sensitivity, labor-intensive and time-consuming. In this study, we constructed a more complete catalogue of lung cancer mutation events including 145 mutated genes. With the genes of this list it may be feasible to develop a NGS kit for lung cancer mutation detection.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000300022
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572013000300022
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.36 n.3 2013
Fonte: | info:eu-repo/semantics/openAccess