Data/hora: 01/06/2024 06:11:44

Provedor de dados: | 74
País: | Brazil
Título: | Evaluation of extracts from Coccoloba mollis using the Salmonella/microsome system and in vivo tests
Autores: | Tsuboy,Marcela Stefanini; Marcarini,Juliana Cristina; Ferreira,Dalva Trevisan; Ferraz,Elisa Raquel Anastácio; Chequer,Farah Maria Drumond; Oliveira,Danielle Palma de; Ribeiro,Lúcia Regina; Mantovani,Mário Sérgio.
Data: | 2010-01-01
Ano: | 2010
Palavras-chave: | Medicinal plants; Coccoloba mollis; Ames test; In vivo comet assay; In vivo micronucleus assay; Polygonaceae.
Resumo: | The common everyday use of medicinal plants is an ancient, and still very widespread practice, whereby the need for studies on their possible toxicity and mutagenic properties. The species Coccoloba mollis has been much used in phytotherapy, mainly in cases involving loss of memory and stress. In order to investigate its genotoxic and mutagenic potential, ethanolic extracts from the leaves and roots underwent Salmonella/microsome assaying (TA98 and TA100 strains, with and without exogenous metabolism - S9), besides comet and micronucleus tests in vivo.There was no significant increase in the number of revertants/plate of Salmonella strains in any of the analyzed root-extract concentrations, although the extract itself was extremely toxic to the Salmonella TA98 strain in the tests carried out with S9 (doses varying from 0.005 to 0.5 µg/plate). On the other hand, the leaf-extract induced mutations in the TA98 strain in the absence of S9 in the highest concentration evaluated, although at very low mutagenic potency (0.004 rev/µg). Furthermore, there was no statistically significant increase in the number of comets and micronuclei, in treatments involving Swiss mice. It was obvious that extracts of Coccoloba mollis, under the described experimental conditions, are not mutagenic.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300027
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572010005000062
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.33 n.3 2010
Fonte: | info:eu-repo/semantics/openAccess