Data/hora: 10/06/2024 17:04:43

Provedor de dados: | 74
País: | Brazil
Título: | Polymorphisms of the DNA repair genes XRCC1 and XRCC3 in a Brazilian population
Autores: | Duarte,Márcia Cristina; Colombo,Jucimara; Rossit,Andréa Regina Baptista; Silva,Ana Elizabete.
Data: | 2005-09-01
Ano: | 2005
Palavras-chave: | DNA repair; XRCC1; XRCC3; Polymorphism; Ethnic variability.
Resumo: | In several DNA repair genes, polymorphisms may result in reduced repair capacity, which has been implicated as a risk factor for various types of cancer. The frequency of the polymorphic alleles varies among populations, suggesting an ethnic distribution of genotypes. We genotyped 300 healthy Southeastern Brazilian individuals (262 of European ancestry and 38 of African ancestry) for polymorphisms of codons 194 and 399 of the XRCC1 base excision repair pathway gene and of codon 241 of the XRCC3 homologous recombination repair pathway gene. The allele frequencies were 0.07 for the Arg194Trp and 0.33 for the Arg399Gln codons of the XRCC1 gene and 0.35 for the Thr241Met codon of the XRCC3 gene. The genotypic frequencies were within Hardy-Weinberg equilibrium. These frequencies showed ethnic variability when compared with those obtained for different populations from several countries.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000300011
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572005000300011
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.28 n.3 2005
Fonte: | info:eu-repo/semantics/openAccess