Data/hora: 10/06/2024 14:16:28

Provedor de dados: | 74
País: | Brazil
Título: | Genotoxic evaluation of sodium nitroprusside in Aspergillus nidulans
Autores: | Chiuchetta,Simone Jurema Ruggeri; Castro-Prado,Marialba Avezum Alves de.
Data: | 2005-12-01
Ano: | 2005
Palavras-chave: | Nitric oxide; Parasexual cycle; Homozygotization index; Conidiation; Mitotic recombination.
Resumo: | The exogenous nitric oxide donor, sodium nitroprusside, evaluated the recombinogenic potential of nitric oxide. Drug inhibited mycelial growth and conidiation in A757 Aspergillus nidulans master strain. Two heterozygous diploid strains, one wild (uvsH+//uvsH+) and the other defective to DNA repair (uvsH//uvsH) were used for recombinagenesis tests. Sodium nitroprusside recombinogenic effect was evaluated by the induction of homozygosis of recessive genes, originally present in heterozygous condition. Results show that sodium nitroprusside (40 muM, 80 muM and 160 muM) is effective in inducing mitotic crossing-over in diploid cells of A. nidulans.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000500023
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572005000500023
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.28 n.4 2005
Fonte: | info:eu-repo/semantics/openAccess