Data/hora: 09/06/2024 13:35:14

Provedor de dados: 	74	
País: 	Brazil	
Título: 	Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients	
Autores: 	Safari-Arababadi,Minoo; Modarressi,Mohammad Hossein; Arababadi,Mohammad Kazemi.	
Data: 	2019-06-01	
Ano: 	2019	
Palavras-chave: 	Innate immunity; Hepatitis B; RIP1; IPS-1.	
Resumo: 	Abstract IPS-1 and RIP1 are the main downstream molecules of RIG1 and MDA5, as intracytoplasmic receptors, which are the main receptors involved in recognition of internal and external viral double-stranded RNA. In this project, mRNA levels of IPS-1 and RIP1 were investigated in the peripheral blood immune cells of chronic hepatitis B (CHB) patients. IPS-1 and RIP1 mRNA levels were measured in 60 CHB patients and 120 healthy subjects, using RT-qPCR technique. A significant increase in expression levels of IPS-1 and RIP1 was found in patients when compared to healthy individuals. There was no correlation between IPS-1 and RIP1expression levels with the serum levels of hepatitis B e-Antigen (HBeAg) and liver enzymes in patients. Based on the results, it seems that IPS-1 and RIP1 can participate in the induction of low chronic inflammation, which is a main cause of liver cirrhosis and hepatocellular carcinoma.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000300337	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/1678-4685-gmb-2018-0071	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.42 n.2 2019	
Fonte: 	info:eu-repo/semantics/openAccess