Data/hora: 02/06/2024 06:23:32

Provedor de dados: | 74
País: | Brazil
Título: | Myeloproliferative syndrome of monosomy 7: a brief report
Autores: | Marques-Salles,Terezinha de Jesus; Soares-Ventura,Eliane Maria; Oliveira,Nathalia Lopes de; Silva,Mariluze; Assis,Reijane; Morais,Vera Lúcia Lins de; Otero,Luize; Fernandez,Teresa; Pombo-de-Oliveira,Maria do Socorro; Muniz,Maria Tereza Cartaxo; Santos,Neide.
Data: | 2008-01-01
Ano: | 2008
Palavras-chave: | Leukemia; Monosomy 7; Myeloproliferative syndrome.
Resumo: | We report the case of a five-month-old black male infant who had recurrent episodes of respiratory infections and also presented anemia and enlargements of the spleen, liver and lymphnodes. Hematological analysis revealed morphological abnormalities with megaloblastic dyserythropoiesis, while fetal hemoglobin assaying showed normal levels. Conventional and molecular cytogenetic analysis revealed monosomy of chromosome 7. Despite all therapeutic efforts during allogenic bone marrow transplantation, the child died due to generalized infection. The clinical and genetic distinctions between monosomy 7 syndrome and myelodysplastic disorders in childhood are discussed.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000100007
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572008000100007
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.31 n.1 2008
Fonte: | info:eu-repo/semantics/openAccess