Data/hora: 10/06/2024 04:59:36

Provedor de dados: 	74	
País: 	Brazil	
Título: 	Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil	
Autores: 	Barbosa,Cynara Gomes; Souza,Claudio Lima; Moura Neto,José Pereira de; Arruda,Maria da Glória Bomfim; Barreto,José Henrique; Reis,Mitermayer Galvão; Goncalves,Marilda Souza.	
Data: 	2008-01-01	
Ano: 	2008	
Palavras-chave: 	AML; CML; MTHFR polymorphisms.	
Resumo: 	Methylenetetrahydrofolate reductase (MTHFR: EC 1.5.1.20) polymorphisms are associated to acute lymphoid leukemia in different populations. We used the polymerase chain reaction and the restriction fragment length polymorphism method (PCR-RFLP) to investigate MTHFR C677T and A1298C polymorphism frequencies in 67 patients with chronic myeloid leukemia (CML), 27 with acute myeloid leukemia FAB subtype M3 (AML-M3) and 100 apparently healthy controls. The MTHFR mutant allele frequencies were as follows: CML = 17.2% for C677T, 21.6% for A1298C; AML-M3 = 22.2% for C677T, 24.1% for A1298C; and controls = 20.5% for C677T, 21% for A1298C. Taken together, our results provide evidence that MTHFR polymorphisms have no influence on the development of CML or AML-M3.	
Tipo: 	Info:eu-repo/semantics/other	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000100005	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/S1415-47572008000100005	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.31 n.1 2008	
Fonte: 	info:eu-repo/semantics/openAccess