Data/hora: 15/06/2024 23:53:24

Provedor de dados: | 74
País: | Brazil
Título: | Genotoxic effects of Tabebuia impetiginosa (Mart. Ex DC.) Standl. (Lamiales, Bignoniaceae) extract in Wistar rats
Autores: | Lemos,Odilon A.; Sanches,Júlio C.M.; Silva,Ícaro E.F.; Silva,Márcio L.A.; Vinhólis,Adriana H.C.; Felix,Mireille A.P.; Santos,Raquel A.; Cecchi,Andréa O.
Data: | 2012-01-01
Ano: | 2012
Palavras-chave: | Tabebuia impetiginosa; Comet assay; Wistar rats; Natural compounds.
Resumo: | Tabebuia sp. is native to tropical rain forests throughout Central and South America. Although the biological and pharmacological effects of bark extracts have been intensely studied, little is known on the extract obtained from the flower. Herein, the genotoxic potential of a flower extract from T. impetiginosa ("ipê roxo") on the blood and liver cells of Wistar rats was evaluated. Experimental procedures involved only male animals. Graduated concentrations of the extract, viz., 100, 300 and 500 mg kg-1 of body weight, were gavage-administered and 24 h latter cells were collected and processed for analysis. With the exception of the 100 mg kg-1 dose, a significant increase in DNA damage was noted, when compared with a negative control group. Although the genotoxic potential of this extract was higher in liver cells, the response in both tissues was related to dose-dependency. Even though DNA damage can be corrected before conversion into mutations, further study is recommended to arrive at a better understanding of incurred biological effects.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000300017
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572012005000030
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.35 n.2 2012
Fonte: | info:eu-repo/semantics/openAccess