Data/hora: 16/06/2024 08:58:31

Provedor de dados: | 74
País: | Brazil
Título: | Effect of organic tomato ( Lycopersicon esculentum ) extract on the genotoxicity of doxorubicin in the  Drosophila  wing spot test
Autores: | Dutra,Elaine S.; Dias,Cristina D.; Araújo,Bethânia C. de; Castro,Antônio J. S.; Nepomuceno,Júlio C.
Data: | 2009-01-01
Ano: | 2009
Palavras-chave: | Antioxidants; Co-genotoxicity; Drosophila melanogaster; Organic tomato; SMART.
Resumo: | The consumption of organic tomatoes (ORTs) reduces the risk of harmful effects to humans and the environment caused by exposure to toxic agrochemicals. In this study, we used the somatic mutation and recombination test (SMART) of wing spots in  Drosophila melanogaster  to evaluate the genotoxicity of ORT and the effect of cotreatment with ORT on the genotoxicity of Doxorubicin ®  (DXR, a cancer chemotherapeutic agent) that is mediated by free radical formation. Standard (ST) cross larvae were treated chronically with solutions containing 25%, 50% or 100% of an aqueous extract of ORT, in the absence and presence of DXR (0.125 mg/mL), and the number of mutant spots on the wings of emergent flies was counted. ORT alone was not genotoxic but enhanced the toxicity of DXR when administered concomitantly with DXR. The ORT-enhanced frequency of spots induced by DXR may have resulted from the interaction of ORT with the enzymatic systems that catalyze the metabolic detoxification of this drug.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000100020
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572009005000008
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.32 n.1 2009
Fonte: | info:eu-repo/semantics/openAccess