Data/hora: 03/06/2024 18:45:42

Provedor de dados: 	74	
País: 	Brazil	
Título: 	Leptin and hypothalamic gene expression in early- and late-maturing Bos indicus Nellore heifers	
Autores: 	Vaiciunas,Aline; Coutinho,Luiz L.; Meirelles,Flávio V.; Pires,Alexandre V.; Silva,Luis Felipe P.	
Data: 	2008-01-01	
Ano: 	2008	
Palavras-chave: 	Bos indicus; Gene expression; Hypothalamus; Leptin; Neuropeptide Y.	
Resumo: 	We investigated wether early-maturing or late-maturing Bos indicus Nellore heifers produced more leptin mRNA in adipose tissues and altered expression of hypothalamic genes related to leptin signaling. Six prepubertal and six pubertal heifers aged about 34 months and weighing 280 kg to 300 kg each were selected from a population of 100 Nellore heifers. Real-time PCR was used to quantify the expression of the leptin gene (LEP) in adipose tissues and the long isoform of the leptin receptor gene (Ob-Rb), the NK2 homeobox 1 hypothalamic marker gene NKX2-1, the suppressor of cytokine signaling 3 gene (SOCS-3), the neuropeptide Y genes (NPY) and the NPY G-protein coupled receptor genes NPY-Y1 and NPY-Y4 in the hypothalamus. Heifers attaining puberty earlier showed significantly greater LEP expression in adipose tissues (p &lt; 0.05) and there was tissue interaction (p &lt; 0.05). Hypothalamic expression of Ob-Rb, NKX2-1, NPY and SOCS-3 did not differ between groups, but in early-maturing heifers there was a tendency for lower expression of NPY-Y1 (8.3-fold less) and NPY-Y4 (14.3-fold less) compared to late-maturing heifers (p = 0.1). These results suggest that a combination of higher LEP expression, lower NPY-Y1 and NPY-Y4 expression could be a factor in regulating puberty in early-maturing B. indicus heifers.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400010	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/S1415-47572008000400010	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.31 n.3 2008	
Fonte: 	info:eu-repo/semantics/openAccess