Data/hora: 09/06/2024 11:33:26

Provedor de dados: 	Genetics and Molecular Biology	
País: 	Brazil	
Título: 	Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil	
Autores: 	Cabral,Cynthia Hatsue Kitayama; Serafim,Édvis Santos Soares; Medeiros,Waleska Rayane Dantas Bezerra de; Fernandes,Thales Allyrio Araújo de Medeiros; Kimura,Elza Miyuki; Costa,Fernando Ferreira; Sonati,Maria de Fátima; Rebecchi,Ivanise Marina Moretti; Medeiros,Tereza Maria Dantas de.	
Data: 	2011-01-01	
Ano: 	2011	
Palavras-chave: 	Haplotypes; Β-globin; Sickle-cell anemia; Brazilian population; S hemoglobin.	
Resumo: 	βS haplotypes were studied in 47 non-related patients with sickle-cell anemia from the state of Rio Grande do Norte, Brazil. Molecular analysis was conducted by PCR/RFLP using restriction endonucleases XmnI, HindIII, HincII and HinfI to analyze six polymorphic sites from the beta cluster. Twenty-seven patients (57.5%) were identified with genotype CAR/CAR, 9 (19.1%) CAR/BEN, 6 (12.8%) CAR/CAM, 1 (2.1%) BEN/BEN, 2 (4.3%) CAR/Atp, 1 (2.1%) BEN/Atp and 1 (2.1%) with genotype Atp/Atp. The greater frequency of Cameroon haplotypes compared to other Brazilian states suggests the existence of a peculiarity of African origin in the state of Rio Grande do Norte.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300009	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/S1415-47572011005000027	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.34 n.3 2011	
Fonte: 	info:eu-repo/semantics/openAccess