Data/hora: 09/06/2024 07:40:56

Provedor de dados: | Genetics and Molecular Biology
País: | Brazil
Título: | Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil
Autores: | Cabral,Cynthia Hatsue Kitayama; Serafim,Édvis Santos Soares; Medeiros,Waleska Rayane Dantas Bezerra de; Fernandes,Thales Allyrio Araújo de Medeiros; Kimura,Elza Miyuki; Costa,Fernando Ferreira; Sonati,Maria de Fátima; Rebecchi,Ivanise Marina Moretti; Medeiros,Tereza Maria Dantas de.
Data: | 2011-01-01
Ano: | 2011
Palavras-chave: | Haplotypes; Β-globin; Sickle-cell anemia; Brazilian population; S hemoglobin.
Resumo: | βS haplotypes were studied in 47 non-related patients with sickle-cell anemia from the state of Rio Grande do Norte, Brazil. Molecular analysis was conducted by PCR/RFLP using restriction endonucleases XmnI, HindIII, HincII and HinfI to analyze six polymorphic sites from the beta cluster. Twenty-seven patients (57.5%) were identified with genotype CAR/CAR, 9 (19.1%) CAR/BEN, 6 (12.8%) CAR/CAM, 1 (2.1%) BEN/BEN, 2 (4.3%) CAR/Atp, 1 (2.1%) BEN/Atp and 1 (2.1%) with genotype Atp/Atp. The greater frequency of Cameroon haplotypes compared to other Brazilian states suggests the existence of a peculiarity of African origin in the state of Rio Grande do Norte.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300009
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572011005000027
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.34 n.3 2011
Fonte: | info:eu-repo/semantics/openAccess