Data/hora: 08/06/2024 15:31:35

Provedor de dados: | 74
País: | Brazil
Título: | Identification of the GTPase superfamily in Mycoplasma synoviae and Mycoplasma hyopneumoniae
Autores: | Borges,Clayton Luiz; Parente,Juliana Alves; Pereira,Maristela; Soares,Célia Maria de Almeida.
Data: | 2007-01-01
Ano: | 2007
Palavras-chave: | Mycoplasma; GTPase superfamily; Genome.
Resumo: | Mycoplasmas are the smallest known prokaryotes with self-replication ability. They are obligate parasites, taking up many molecules of their hosts and acting as pathogens in men, animals, birds and plants. Mycoplasma hyopneumoniae is the infective agent of swine mycoplasmosis and Mycoplasma synoviae is responsible for subclinical upper respiratory infections that may result in airsacculitis and synovitis in chickens and turkeys. These highly infectious organisms present a worldwide distribution and are responsible for major economic problems. Proteins of the GTPase superfamily occur in all domains of life, regulating functions such as protein synthesis, cell cycle and differentiation. Despite their functional diversity, all GTPases are believed to have evolved from a single common ancestor. In this work we have identified mycoplasma GTPases by searching the complete genome databases of Mycoplasma synoviae and Mycoplasma hyopneumoniae, J (non-pathogenic) and 7448 (pathogenic) strains. Fifteen ORFs encoding predicted GTPases were found in M. synoviae and in the two strains of M. hyopneumoniae. Searches for conserved G domains in GTPases were performed and the sequences were classified into families. The GTPase phylogenetic analysis showed that the subfamilies were well resolved into clades. The presence of GTPases in the three strains suggests the importance of GTPases in 'minimalist' genomes.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000200007
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572007000200007
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.30 n.1 suppl.0 2007
Fonte: | info:eu-repo/semantics/openAccess