Data/hora: 06/06/2024 18:05:47

Provedor de dados: | 74
País: | Brazil
Título: | Dose assessment by quantification of chromosome aberrations and micronuclei in peripheral blood lymphocytes from patients exposed to gamma radiation
Autores: | Silva-Barbosa,Isvânia; Pereira-Magnata,Símey; Amaral,Ademir; Sotero,Graça; Melo,Homero Cavalcanti.
Data: | 2005-09-01
Ano: | 2005
Palavras-chave: | Chromosome aberrations; Micronuclei; Biodosimetry; Partial-body irradiation; Lymphocyte.
Resumo: | Scoring of unstable chromosome aberrations (dicentrics, rings and fragments) and micronuclei in circulating lymphocytes are the most extensively studied biological means for estimating individual exposure to ionizing radiation (IR), which can be used as complementary methods to physical dosimetry or when the latter cannot be performed. In this work, the quantification of the frequencies of chromosome aberrations and micronuclei were carried out based on cytogenetic analyses of peripheral blood samples from 5 patients with cervical uterine cancer following radiotherapy in order to evaluate the absorbed dose as a result of partial-body exposure to 60Co source. Blood samples were collected from each patient in three phases of the treatment: before irradiation, 24 h after receiving 0.08 Gy and 1.8 Gy, respectively. The results presented in this report emphasize biological dosimetry, employing the quantification of chromosome aberrations and micronuclei in lymphocytes from peripheral blood, as an important methodology of dose assessment for either whole or partial-body exposure to IR.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000300021
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572005000300021
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.28 n.3 2005
Fonte: | info:eu-repo/semantics/openAccess