Data/hora: 02/06/2024 17:44:52

Provedor de dados: | 77
País: | Chile
Título: | Moringa oleifera Impairs the Morphology and Functions of the Kidney in Adult Wistar Rats
Autores: | Akinlolu,Abdulazeez Adelaja; Ghazali,Olaide Kamal; Ameen,Oloduowo Mubarak; Oyebanji,Seunayo Comfort; Omotoso,Gabriel Olaiya; Enaibe,Bernard Ufuoma.
Data: | 2014-06-01
Ano: | 2014
Palavras-chave: | Moringa oleifera; Toxicity profile; Kidney.
Resumo: | We tested the hypothesis that Moringa oleifera impairs the morphology and functions of the kidney in rats. Twenty-four adult male Wistar rats were employed in the study. Rats of Control Group I received physiological saline while rats of Groups II ­ IV received 250, 500 and 750 mg/kg bodyweight of methanolic extract of Moringa oleifera respectively for twenty one days. No behavioral anomalies were observed in rats of Groups I ­ IV. Rats of Control Group I gained statistically significant increased bodyweight while rats of Groups II ­ IV experienced non-significant decreased bodyweight during experimental procedure. (P0.05). No statistical significant differences (P0.05) were observed in the analyses of the relative weights of kidneys of rats of Groups I ­ IV. Histological examinations showed normal cyto-architecture of the kidneys of rats of Group I while the Capsular spaces of the kidneys of rats of Groups II ­ IV appeared wider than those of Group I. Statistical analyses showed significant higher levels (P0.05) of Alanine and Aspartate Transaminases, and serum urea in rats of Groups II ­ IV in a non- dose-dependent manner when compared to rats of Group I. Our findings are consistent with the stated hypothesis.
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000200016
Editor: | Sociedad Chilena de Anatomía
Formato: | text/html
Fonte: | International Journal of Morphology  v.32 n.2 2014