Data/hora: 10/06/2024 13:37:14

Provedor de dados: | 77
País: | Chile
Título: | The Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Tooth Development in Rats
Autores: | Mahmut,Koparal; Faruk,Er; Engin,Deveci; Dilek,Yavuz.
Data: | 2015-03-01
Ano: | 2015
Palavras-chave: | Propineb; MMP2; Tooth buds; VEGF.
Resumo: | Dithiocarbamate propinebs are organometal fungicides that are widely used for the control of diseases in plants. In this study, pregnant female rats received 400 ppm propineb concentrations in 5 ml distilled water for 16 days of gestation, and then infant rats were obtained by cesarean section. In the histological analysis on the frontal sections, the use of propineb was found effective on odontoblast cell hyperplasia, cell infiltration in the dental papilla, and degeneration in the mesenchymal cells of the outer enamel. The expression of MMP-2 (Matrix Metalloproteinase-2) and VEGF (Endothelial cell growth factor) in the connective tissue was evaluated by immunohistochemistry. The drinking water given to the mothers in propineb tooth bud, enamel and dentin, resulted in morphological changes suggestive of a delay in formation, which cross the placental barrier and possibly affect the tooth development.
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100014
Editor: | Sociedad Chilena de Anatomía
Formato: | text/html
Fonte: | International Journal of Morphology  v.33 n.1 2015