Data/hora: 09/06/2024 11:20:17

Provedor de dados: | 77
País: | Chile
Título: | Maternal Chronic Stress Induces Premature Telencephalic Vesicles Development
Autores: | Mugnaini,María Teresa; Soñez,Carlos Alberto; Rolando,Alicia Nélida; Romanini,María Cristina; Bozzo,Aída Andrea; Pastorino,Isabel Cecilia; Gauna,Héctor Fernando; Paz,Dante Agustín.
Data: | 2006-01-01
Ano: | 2006
Palavras-chave: | Telencephalic vesicle; Chronic stress; Morphometric analysis; Rats.
Resumo: | Exposure to physical or psychological stress causes brain damage ranging from minimal behavioural alterations to different neurodegeneration degrees implying the overproduction of oxidative-nitrosative compounds, apoptosis and cell proliferation. In the present investigation, we have analysed the effect of the chronic stress by immobilisation applied to pregnant rats over the forebrain development of the embryos. The morphometric analyses showed an accelerated evagination of the telencephalic vesicles in 12 days old fetus from stressed mothers. The forebrain perimeter and the thickness showed significative differences in relation to age-matched controls. This stress effect seemed reversible during subsequent gestational stages. This is the first work showing a transient acceleration in the development induced by the gestational stress. Our model provides a new tool for studying the effect of the stress on the development
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000500001
Editor: | Sociedad Chilena de Anatomía
Formato: | text/html
Fonte: | International Journal of Morphology  v.24 n.4 2006