Data/hora: 09/06/2024 08:49:48

Provedor de dados: | International Journal of Morphology
País: | Chile
Título: | Toxoplasma gondii Induces Death of Gastric Myenteric Neurons in Rats
Autores: | Alves,Marcelo Sardeto; Silva,Aristeu Vieira da; Bianchi,Larissa Renata de Oliveira; Araújo,Eduardo José de Almeida; Sant'Ana,Débora de Mello Gonçales.
Data: | 2011-03-01
Ano: | 2011
Palavras-chave: | Stomach; Toxoplasmosis; Enteric nervous system; Myenteric plexus.
Resumo: | The aim of the study was quantifying and morphologically analyzing the myenteric neurons of the small and large gastric curvatures of the glandular stomach of rats infected the tachyzoites of the Toxoplasma gondii for 30 days. Ten male rats were assigned into two groups: Control Group (CG) and Experimental Group (EG). The animals from the CG received saline solution orally whereas the EG animals received 104 tachyzoites of the T. gondii genotype III strain (BTU II). After 30 days, euthanasia was conducted for the removal of the stomach, which was dissected under the stereomicroscope for removal of the tunica mucosa and the tela submucosa. Whole mounts were stained with Giemsa. Quantification of the myenteric neurons was conducted by using a 40X-objective microscope in 40 microscopic fields for the region of the small gastric curvature and 40 fields for the large gastric curvature of the glandular stomach of the animals from both groups. The cell body of 50 myenteric neurons from each region was measured for each animal. Chronic experimental infection caused by the genotype III strain of Toxoplasma gondii was verified to reduce myenteric neuron density only in the small gastric curvature region of the glandular stomach, not resulting in significant changes in the size of the neurons.
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000100048
Editor: | Sociedad Chilena de Anatomía
Formato: | text/html
Fonte: | International Journal of Morphology  v.29 n.1 2011