Data/hora: 03/06/2024 16:42:23

Provedor de dados: | 77
País: | Chile
Título: | Morphometrical Analysis of the Effect of Nicotine Administration on Brain's Prefrontal Region in Male Rat
Autores: | Jalili,C; Salahshoor,M. R; Khademi,F; Jalili,P; Roshankhah,S. H.
Data: | 2014-09-01
Ano: | 2014
Palavras-chave: | Morphometric; Prefrontal cortex; Nicotine; Rat.
Resumo: | Nicotine is the most important alkaloid compound in tobacco. One of the major effects of nicotine is stimulation of mesocorticolimbic system. Prefrontal cortex plays a pivotal role in personality and mental state. It is considered the main cause of addiction as it is located in mesocorticolimbic dopamine system. Twenty four male rats were divided into four groups based on nicotine administration dose (0, 0.5, 1 and 1.5 g/kg). After animals were anesthetized, their brains were fixed using transcardiac method. Tissue processing and Golgi staining were performed and the stained tissue sections were analyzed by optic microscope and Motic software. By increasing the dose, nicotine significantly decreased the number of neuronal processes. In the higher dose, nicotine caused a significant decrease and increase in the size of pericarions and dendritic spines, respectively (p&lt;0.05). Nicotine administration can decrease the size of pericarion and number of dendritic spines in the prefrontal cortex.
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300003
Editor: | Sociedad Chilena de Anatomía
Formato: | text/html
Fonte: | International Journal of Morphology  v.32 n.3 2014