Data/hora: 01/06/2024 06:40:50

Provedor de dados: | Journal of Venomous Animals and Toxins
País: | Brazil
Título: | The use of antivenom reverses hematological and osmotic fragility changes of erythrocytes caused by indian red scorpion Mesobuthus tamulus concanesis POCOCK in experimental envenoming
Autores: | RADHA KRISHNA MURTHY,K.; ABBAS ZARE,M.
Data: | 2001-01-01
Ano: | 2001
Palavras-chave: | Antivenom; Scorpion venom; Mesobuthus tamulus concanesis POCOCK; Osmotic fragility; Hematology; PCV; MCHC; Hb; Plasma Hb; ECG changes.
Resumo: | Acute myocarditis was induced in experimental dogs by subcutaneous (SC) injection of 3mg/kg of scorpion venom from Mesobuthus tamulus concanesis POCOCK (earlier called Buthus tamulus). An increase in hemoglobin (Hb), mean corpuscular hemoglobin concentration (MCHC), packed cell volume (PCV), plasma hemoglobin (Plasma Hb) levels, and increased osmotic fragility of erythrocytes in vivo was observed after envenoming. An increase in osmotic fragility of red blood cells (RBC) was also observed when the blood in vitro was incubated with different concentrations of scorpion venom. Species- specific scorpion antivenom (SAV) was administered to different groups of animals at different time intervals following scorpion envenoming. This resulted in a decrease in Hb, MCHC, PCV, and plasma Hb levels in the envenomed animals and reversal of osmotic fragility changes of erythrocytes. It has been suggested that scorpion venom causes an autonomic storm releasing massive amounts of counter-regulatory hormones, such as catecholamines, angiotensin-II, glucagon, cortisol, and changes in insulin secretion resulting in hematological and osmotic fragility changes of erythrocytes. Administration of SAV effectively neutralized, prevented, and reversed scorpion venom toxicity and related osmotic fragility changes of erythrocytes.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302001000100008
Editor: | Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP
Relação: | 10.1590/S0104-79302001000100008
Formato: | text/html
Fonte: | Journal of Venomous Animals and Toxins  v.7 n.1 2001
Fonte: | info:eu-repo/semantics/openAccess