Data/hora: 08/06/2024 19:02:29

Provedor de dados: | 80
País: | Brazil
Título: | Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxin
Autores: | Nencioni,ALA; Barreto,SA; Lebrun,I; Florio,JC; Lourenço,GA; Dorce,VAC.
Data: | 2009-01-01
Ano: | 2009
Palavras-chave: | Scorpion toxin; Microdialysis; Hippocampus; Neurotransmitters; Neurodegeneration; Riluzole.
Resumo: | TsTX is an α-type sodium channel toxin that stimulates the discharge of neurotransmitters from neurons. In the present study we investigated which neurotransmitters are released in the hippocampus after TsTX injection and if they are responsible for electrographic or histopathological effects. Microdialysis revealed that the toxin increased glutamate extracellular levels in the hippocampus; however, levels of gamma-aminobutyric acid (GABA), glycine, 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) were not significantly altered. Neurodegeneration in pyramidal cells of hippocampus and electroencephalographic alterations caused by the toxin were blocked by pretreatment with riluzole, a glutamate release inhibitor. The present results suggest a specific activity of TsTX in the hippocampus which affects only glutamate release.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000200007
Editor: | Centro de Estudos de Venenos e Animais Peçonhentos
Relação: | 10.1590/S1678-91992009000200007
Formato: | text/html
Fonte: | Journal of Venomous Animals and Toxins including Tropical Diseases  v.15 n.2 2009
Fonte: | info:eu-repo/semantics/openAccess