Data/hora: 09/06/2024 09:42:12

Provedor de dados: | Journal of Venomous Animals and Toxins Including Tropical Diseases
País: | Brazil
Título: | Post-exposure treatment of Ebola virus using passive immunotherapy: proposal for a new strategy
Autores: | Chippaux,Jean-Philippe; Boyer,Leslie V; Alagón,Alejandro.
Data: | 2015-01-01
Ano: | 2015
Palavras-chave: | Ebola; Epidemics; Immunotherapy; Prophylaxis; Africa.
Resumo: | Background Better treatments are urgently needed for the management of Ebola virus epidemics in Equatorial Africa. Methods We conducted a systematic review of the literature on the use of passive immunotherapy for the treatment or prevention of Ebola virus disease. We placed findings from this review into the context of passive immunotherapy currently used for venom-induced disease, and recent improvements in manufacturing of polyvalent antivenom products. Results Passive immunotherapy appears to be one of the most promising specific treatments for Ebola. However, its potential has been incompletely evaluated, considering the overall experience and recent improvement of immunotherapy. Development and use of heterologous serum derivatives could protect people exposed to Ebola viruses with reasonable cost and logistics. Conclusion Hyperimmune equine IgG fragments and purified polyclonal whole IgG deserve further consideration as treatment for exposure to the Ebola virus.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100203
Editor: | Centro de Estudos de Venenos e Animais Peçonhentos
Relação: | 10.1186/s40409-015-0003-1
Formato: | text/html
Fonte: | Journal of Venomous Animals and Toxins including Tropical Diseases  v.21 2015
Fonte: | info:eu-repo/semantics/openAccess