Data/hora: 01/06/2024 16:27:30

Provedor de dados: | 80
País: | Brazil
Título: | Experimental Tityus serrulatus scorpion envenomation: age- and sex-related differences in symptoms and mortality in mice
Autores: | MB,Pucca; EC,Roncolato; LB,Campos; FS,Fernandes; GR,Mendes; TB,Bertolini; FA,Cerni; JE,Barbosa.
Data: | 2011-01-01
Ano: | 2011
Palavras-chave: | Scorpions; LD50; Stings; Age factors; Gender.
Resumo: | Among the various methods for evaluating animal venom toxicity, the calculation of the median lethal dose (LD50) is the most widely used. Although different protocols can be used to calculate the LD50, the source of the venom and the method of extraction, as well as the strain, age, and sex of the animal model employed, should be taken into consideration. The objective of the present study was to evaluate the influence of sex and age on the toxicity of Tityus serrulatus scorpion venom in Swiss mice. Although the symptoms of envenomation were similar in male and female animals, female mice proved to be more resistant to the venom. In females, age had no impact on the susceptibility to scorpion envenomation. Male mice were more sensitive to T. serrulatus venom. Moreover, in males, age was an important parameter since sensitivity to the venom increased with age.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000300013
Editor: | Centro de Estudos de Venenos e Animais Peçonhentos
Relação: | 10.1590/S1678-91992011000300013
Formato: | text/html
Fonte: | Journal of Venomous Animals and Toxins including Tropical Diseases  v.17 n.3 2011
Fonte: | info:eu-repo/semantics/openAccess