Data/hora: 07/06/2024 18:42:07

Provedor de dados: | Journal of Venomous Animals and Toxins Including Tropical Diseases
País: | Brazil
Título: | Antivenom action on renal effects induced by Thalassophryne nattereri venom
Autores: | Martins,AMC; Barbosa,PSF; Sousa,DF; Alves,CD; Menezes,DB; Lima,C; Lopes-Ferreira,M; Fonteles,MC; Monteiro,HSA.
Data: | 2009-01-01
Ano: | 2009
Palavras-chave: | Thalassophryne nattereri; Antivenom; Kidney.
Resumo: | Thalassophryne nattereri (niquim) is a venomous fish responsible for numerous accidents involving fishermen in northern and northeastern Brazil. The aim of the present investigation was to evaluate the action of antivenom on renal effects caused by Thalassophryne nattereri venom. Isolated kidneys of Wistar rats were perfused with a previously dialyzed Krebs-Henseleit solution containing 6 g% bovine serum albumin. The antivenom action was studied through perfusion pressure (PP), renal vascular resistance (RVR), urinary flow (UF) and glomerular filtration rate (GFR). The niquim venom (1 µg/mL), the antivenom alone (1 µg/mL) or the venom incubated with antivenom were added to the system 30 minutes after the beginning of each perfusion. Previous works have shown venom induced-alterations of renal function parameters. In the isolated rat kidney, T. nattereri venom (1 µg/mL) increased the perfusion pressure and renal vascular resistance at 60, 90 and 120 minutes. UF and GFR also increased at 60, 90 and 120 minutes when compared with the control group; however, no effects were observed on the percent of sodium (%TNa+control = 81.1 ±0.86; %TNa+60 = 78.04 ±1.18; %TNa+90 = 76.16 ±3.34; %TNa+120 = 79.49 ±0.87) and potassium (%TK+control = 72.29 ±1.12; %TK+60 = 75.41 ±0.65; %TK+90 = 71.23 ±2.55; %TK+120 = 76.62 ±1.04) tubular transport. The administration of the antivenom (1 µg/mL) incubated with venom (1 µg/mL) reduced the changes in PP, RVR, UF and GFR provoked by Thalassophryne nattereri venom. The group perfused with venom alone showed a moderate deposit of a proteinaceous material in the tubules and urinary space. The group perfused with the antivenom presented similar results to the control group. In conclusion, the antivenom was able to decrease the effects induced by T. nattereri venom in isolated rat kidney.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000100011
Editor: | Centro de Estudos de Venenos e Animais Peçonhentos
Relação: | 10.1590/S1678-91992009000100011
Formato: | text/html
Fonte: | Journal of Venomous Animals and Toxins including Tropical Diseases  v.15 n.1 2009
Fonte: | info:eu-repo/semantics/openAccess