Data/hora: 02/06/2024 05:31:02

Provedor de dados: | 80
País: | Brazil
Título: | Interleukin 8 (-251 T&amp;gt;A) polymorphism in children and teenagers infected with Helicobacter pylori
Autores: | Saes,Marina; Labio,Roger Willian de; Rasmussen,Lucas Trevizani; Payão,Spencer Luiz Marques.
Data: | 2017-01-01
Ano: | 2017
Palavras-chave: | Helicobacter pylori Interleukin 8 Polymorphism -251 (T&amp;gt; A) Gastric disease.
Resumo: | Abstract  Background Helicobacter pylori (H. pylori) is a gram-negative bacterium that colonizes the human stomach and causes a variety of gastric diseases. This study evaluated the correlations between the -251 (T&gt;A) (rs4073) polymorphism of interleukin-8 (IL-8), the etiology of gastric disease, and H. pylori infection in pediatric and adolescent patients.  Methods  DNA samples were obtained from 285 gastric biopsies from pediatric patients. H. pylori was detected by PCR, whereas PCR-RFLP was used to characterize the -251 (T&gt;A) polymorphism of IL-8.  Results  The histological analysis revealed the presence of gastritis in 158 patients (55.44%). H. pylori was found in 71 samples (24.9%). The -251 (T&gt;A) polymorphism revealed that 58 (29.47%) samples were TT, 143 (50.18%) samples were TA, and 84 (20.35%) samples were AA.  Conclusions  Our findings suggest that IL8-251 A allele may be an important risk factor for the development of gastric disease when associated with H. pylori infection.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100601
Editor: | Centro de Estudos de Venenos e Animais Peçonhentos
Relação: | 10.1186/s40409-017-0113-z
Formato: | text/html
Fonte: | Journal of Venomous Animals and Toxins including Tropical Diseases  v.23 2017
Fonte: | info:eu-repo/semantics/openAccess