Data/hora: 11/06/2024 02:23:22

Provedor de dados: 	89	
País: 	Brazil	
Título: 	Probiotic Lactobacilli Improved Growth Performance and Attenuated Salmonella Typhimurium Infection Via Jak/Stat Signaling in Broilers	
Autores: 	Shi,H; Deng,X; Deng,Q; Liu,Z; Liu,N.	
Data: 	2021-01-01	
Ano: 	2021	
Palavras-chave: 	IFNγ; Interleukin; Salmonella Typhimurium load; TNFα.	
Resumo: 	ABSTRACT This study aimed to investigate the effect of Lactobacillus plantarum DPP8 and Lactobacillus acidophilus C7282 in feed supplementation on growth performance, Salmonella invasion, inflammation, and mediating signaling in broilers infected with Salmonella Typhimurium (S. Typhimurium). A total of 240 broilers at day old were randomly allocated into four groups, orally infected with S. Typhimurium and supplemented with individual or combined Lactobacilli DPP8 and C7282 at doses of 0 (control), 1010 (individual), or 2.0 × 1010 (combination) cfu/kg of diet for 21 d. The results showed that supplementing Lactobacilli improved (p&lt;0.05) feed intake and body weight gain and decreased (p&lt;0.05) S. Typhimurium load in the caecum, harder gland, spleen and bursa of Fabricius. Also, the supplements decreased (p&lt;0.05) interleukin (1β/2/4), tumor necrosis factor α and interferon γ in the serum, enhanced (p&lt;0.05) interleukin 10, and downregulated gene expressions of inflammatory mediators including Janus kinase (Jak2/3), signal transducer and activator of transcription protein (STAT3/4/5/6) in the intestinal mucosa. In contrast, diets containing DPP8 exhibited greater effects on the inhibition of the pathogen and inflammatory response than C7282. The obtained data suggest that Lactobacilli C7282 and DPP8 can be used as feed additives to inhibit colonization and translocation of S. Typhimurium and inflammatory responses via downregulating Jak/STAT signaling in broilers.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2021000100302	
Editor: 	Fundação APINCO de Ciência e Tecnologia Avícolas	
Relação: 	10.1590/1806-9061-2020-1328	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Poultry Science  v.23 n.1 2021	
Fonte: 	info:eu-repo/semantics/openAccess