Data/hora: 13/06/2024 04:01:09

Provedor de dados: | Revista Brasileira de Ciência Avícola
País: | Brazil
Título: | In Vivo Detoxification of Ochratoxin A by Highly Porous Magnetic Nanocomposites Prepared from Coconut Shell
Autores: | Gulfam,N; Zahoor,M; Khisroom,M; Khan,FA.
Data: | 2018-12-01
Ano: | 2018
Palavras-chave: | Serum alanine transferase; Alkaline phosphatase; Clinical signs; Gross lesions.
Resumo: | ABSTRACT The current study was conducted to elucidate the clinical effect of ochratoxin A in Gallus gallusdomesticus and to ameliorate its toxic effects by the development and characterization of highly porous carbon-based adsorbent derived from coconut shell. A series of experiments were performed on one day-old chicks (Group A to F). Clinical signs of the positive control (group B fed on 400 ppb ochratoxin A contaminated feed) included depression, diarrhea, increased water intake, low body weight, high degree of genotoxicity, swollen and hemorrhagic kidneys and liver. Serum alanine amino transferase (ALT), alkaline phosphatase (ALP), creatinine and urea concentration significantly increased while albumin, globulin and total proteins were found significantly low. All these lead to increased mortality. Among adsorbents treated groups, chickens in group C (0.3% of the prepared adsorbent mixed in OTA contaminated feed) and D (0.6% of the prepared adsorbent mixed in Ochratoxin A (OTA) contaminated feed) showed very low pathological effects while group E (0.9% of the prepared adsorbent mixed in OTA contaminated feed) and F (1.2% of the prepared adsorbent mixed in OTA contaminated feed) showed normal behavior, blood biochemistry and well maintained histological structure like that in group A. As a whole, the adsorbents treated groups fed with ochratoxin A contaminated feed, supplemented with different levels of the prepared adsorbent helped to ameliorate the toxic effects of OTA and nearly showed normal clinical signs.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2018000400675
Editor: | Fundação APINCO de Ciência e Tecnologia Avícolas
Relação: | 10.1590/1806-9061-2017-0702
Formato: | text/html
Fonte: | Brazilian Journal of Poultry Science  v.20 n.4 2018
Fonte: | info:eu-repo/semantics/openAccess