Data/hora: 02/06/2024 17:53:15

Provedor de dados: | Revista Brasileira de Fruticultura
País: | Brazil
Título: | Chemical composition, anti-Trypanosoma cruzi and cytotoxic activities of the essential oil from green fruits of Protium ovatum (BURSERACEAE)
Autores: | Estevam,Elisângela Barbosa Borges; Alves,Cássia Cristina Fernandes; Esperandim,Viviane Rodrigues; Cazal,Cristiane de Melo; Souza,Alex Fonseca; Miranda,Mayker Lazaro Dantas.
Data: | 2018-01-01
Ano: | 2018
Palavras-chave: | Protium ovatum; SS-myrcene; Fruits; Essential oil; Trypanosoma cruzi; Cytotoxic analysis.
Resumo: | Abstract  Chagas disease is a major neglected tropical disease caused by Trypanosoma cruzi. It has been treated with the antiparasitic drugs nifurtimox and benzonidazole, which cause several side effects. The market for natural products has considerably grown lately and the use of plants has become an alternative to the development of novel drugs to cure the disease. Therefore, this study aimed at describing the chemical analysis of the essential oil from green fruits of Protium ovatum and evaluating their trypanocidal and cytotoxic potential. The essential oil was obtained by Clevenger hydrodistillation whereas its chemical composition was determined by gas chromatography coupled to mass spectrometry (GC-MS). The major compounds found in the essential oil from green fruits of P. ovatum were ß-myrcene (62.0 %), a-pinene (11.3 %) and limonene (7.3 %). To the best of our knowledge, this was the first time that the chemical composition of the essential oil from green fruits of P. ovatum was described. Results showed that the essential oil had strong trypanocidal activity against trypomastigote forms of theY strain of Trypanosoma cruzi (IC50 = 1.2 µg/mL). In addition, the essential oil from green fruits of P. ovatum did not display cytotoxicity against LLCMK2 adherent epithelial cell at the concentration range under analysis (CC50 = 550.3 µg/mL). As a result, it is an excellent option for the development of novel antiparasitic drugs.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-29452018000106001
Editor: | Sociedade Brasileira de Fruticultura
Relação: | 10.1590/0100-29452018794
Formato: | text/html
Fonte: | Revista Brasileira de Fruticultura  v.40 n.1 2018
Fonte: | info:eu-repo/semantics/openAccess