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Provedor de dados:  Ciênc. Tecnol. Aliment.
País:  Brazil
Título:  Antimicrobial and anti-inflammatory activities of Apis mellifera honey on the Helicobacter pylori infection of Wistar rats gastric mucosa
Autores:  AMARAL,Thiago Yamamoto
PADILHA,Igor Gomes
PRESÍDIO,Gustavo Alvares
SILVEIRA,Edmo Arruda Aguiar Sobreira da
DUARTE,Alysson Wagner Fernandes
BARBOSA,Ana Paula Fernandes
BEZERRA,Antônio Fernando de Souza
LÓPEZ,Ana Maria Queijeiro
Data:  2017-12-01
Ano:  2017
Palavras-chave:  Gastritis
Peptic ulcer
Antioxidant
Anti-inflammatories
Antibiotic
Resumo:  Abstract Considering that Helicobacter pylori, a bacterium able to colonize the upper gastrointestinal tract and cause mucosal injury, not always can be effectively eradicated by the traditional approaches, there is an interest in alternative therapies until a vaccine be available. Honey is a food supplement with high carbohydrate content and antioxidant activity, as well as broad antimicrobial spectrum. After analyzing the physicochemical and in vitro antimicrobial properties of an Apis mellifera honey from the Atlantic forest of Alagoas / Brazil, the purpose of the present work was evaluate its in vivo effects against Helicobacter pylori in the gastric mucosa of Wistar rats. First, it was verified the success of inoculation/infection of the pathogen in the gastric mucosa of the rats, through the subsequent removal of their stomachs for histological analysis (hematoxylin and eosin stain and Giemsa stain). Then, four groups of animals were treated with sterilized distilled deionized water, the Apis mellifera honey, a combination of omeprazole, amoxicillin and clarithromycin, and an association of such medicines and honey (1:1). Except the control, all treatments were effective in combating infection, however, honey reduced the inflammatory process, whilst the antibiotics increase the number of eosinophils.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612017000500034
Editor:  Sociedade Brasileira de Ciência e Tecnologia de Alimentos
Relação:  10.1590/1678-457x.31016
Formato:  text/html
Fonte:  Food Science and Technology v.37 suppl.1 2017
Direitos:  info:eu-repo/semantics/openAccess
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