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Provedor de dados:  Repositório Alice
País:  Brazil
Título:  Patterns and Processes of Mycobacterium bovis Evolution Revealed by Phylogenomic Analyses.
Autores:  PATANE, J. S. L.
MARTINS JUNIOR, J.
CASTELÃO, A. B.
NISHIBE, C.
MONTERA, L.
BIGI, F.
ZUMÁRRAGA, M. J.
CATALDI, A. A.
FONSECA JUNIOR, A.
ROXO, E.
OSÓRIO, A. L. A. R.
JORNGE, K. S.
THACKER, T. C.
ALMEIDA, N. F.
ARAUJO, F. R.
SETUBAL, J. C.
Data:  2017-10-13
Ano:  2017
Palavras-chave:  Phylogenomics
Tuberculose bovina
Filogenômica
Família PE / PPE
Mycobacterium bovis
Epidemiologia
Mycobacterium bovis
Bovine tuberculosis
Resumo:  Mycobacterium bovis is an important animal pathogen worldwide that parasitizes wild and domesticated vertebrate livestock as well as humans. A comparison of the five M. bovis complete genomes from the United Kingdom, South Korea, Brazil, and the United States revealed four novel large-scale structural variations of at least 2,000 bp.Acomparative phylogenomic study including 2,483 core genes of 38 taxa from eight countries showed conflicting phylogenetic signal among sites. By minimizing this effect,we obtained a tree that better agreeswith sampling locality. Results supported a relatively basal position of African strains (all isolated from Homo sapiens), confirming that Africa was an important region for early diversification and that humans were one of the earliest hosts. Selection analyses revealed that functional categories such as ?Lipid transport and metabolism,? ?Cell cycle control, cell division, chromosome partitioning? and ?Cell motility? were significant for the evolution of the group, besides other categories previously described, showing importance of genes associated with virulence and cholesterolmetabolism in the evolution of M. bovis. PE/PPE genes,many ofwhich are known to be associated with virulence, were major targets for large-scale polymorphisms, homologous recombination, and positive selection, evincing for the first time a plethora of evolutionary forces possibly contributing to differential adaptability in M. bovis. By assuming different priors, US strains originated and started to diversify around 150?5,210 ya. By further analyzing the largest set of US genomes to date (76 in total), obtained from 14 host species,we detected that hosts were not clustered in clades (except for a few cases), with some faster-evolving strains being detected, suggesting fast and ongoing reinfections across host species, and therefore, the possibility of new bovine tuberculosis outbreaks.

bitstream/item/165055/1/Patterns-and-processes-of-Mycobacterium-bovis.pdf
Tipo:  Artigo em periódico indexado (ALICE)
Idioma:  Inglês
Identificador:  16861

http://www.alice.cnptia.embrapa.br/alice/handle/doc/1077365

10.1093/gbe/evx022
Editor:  Genome Biology and Evolution, v. 9, n. 3, p. 521-535, March 2017.
Relação:  Embrapa Gado de Corte - Artigo em periódico indexado (ALICE)
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