| Registro completo |
| Provedor de dados: |
Repositório Alice
|
| País: |
Brazil
|
| Título: |
Natural deep eutectic solvent (NADES): A strategy to improve the bioavailability of blueberry phenolic compounds in a ready-to-use extract.
|
| Autores: |
SILVA, D. T. da
SMANIOTTO, F. A.
COSTA, I. F.
BARANZELLI, J.
MULLER, A.
SOMACAL, S.
MONTEIRO, C. S.
VIZZOTTO, M.
RODRIGUES, E.
BARCIA, M. T.
EMANUELLI, T.
|
| Data: |
2021-12-17
|
| Ano: |
2021
|
| Palavras-chave: |
Composto
Mirtilo
Extrato
|
| Resumo: |
This study investigated whether a ready-to-use extract obtained using a natural deep eutectic solvent (NADES) affects the pharmacokinetic profile of blueberry phenolic compounds compared to organic solvent (SORG)-extracted compounds. SORG extract was administered as an aqueous solution after solvent removal. Wistar rats received a single dose of crude extract of blueberry obtained using NADES (CE-NADES) or SORG (CE-SORG), followed by LC-DAD-MS/MS analysis of blood and cecal feces. Non-compartmental pharmacokinetic analysis revealed that CE-NADES increased the bioavailability of anthocyanins by 140% compared to CE-SORG. CE-NADES increased the stability of phenolic compounds during in vitro digestion by delaying gastric chyme neutralization. These results suggest that besides being an eco-friendly solvent for the extraction of phytochemicals, choline chloride:glycerol:citric acid-based NADES can be used as a ready-to-use vehicle for increasing oral absorption of bioactive compounds such as anthocyanins.
|
| Tipo: |
Artigo de periódico
|
| Idioma: |
Inglês
|
| Identificador: |
Food Chemistry, v. 364, 130370, Dec. 2021.
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1138030
doi.org/10.1016/j.foodchem.2021.130370
|
| Direitos: |
openAccess
|
|
