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Provedor de dados:  IPB - Escola Superior Agrária
País:  Portugal
Título:  2-Styrylchromones as novel inhibitors of xanthine oxidase. A structure-activity study
Autores:  Fernandes, Eduarda
Carvalho, Félix
Silva, Artur
Santos, Clementina M.M.
Pinto, Diana
Cavaleiro, José
Bastos, Maria de Lourdes
Data:  2011-04-04
Ano:  2002
Palavras-chave:  2-styrylchromones
Allopurinol
Benzopyrone
Xanthine oxidase inhibition
Resumo:  The purpose of this study was the evaluation of the xanthine oxidase (XO) inhibition produced by some synthetic 2-styrylchromones. Ten polyhydroxylated derivatives with several substitution patterns were synthesised, and these and a positive control, allopurinol, were tested for their effects on XO activity by measuring the formation of uric acid from xanthine. The synthesised 2-styrylchromones inhibited xanthine oxidase in a concentration-dependent and non-competitive manner. Some IC50 values found were as low as 0.55mM, which, by comparison with the IC50 found for allopurinol (5.43 mM), indicates promising new inhibitors. Those 2-styrylchromones found to be potent XO inhibitors should be further evaluated as potential agents for the treatment of pathologies related to the enzyme’s activity, as is the case of gout, ischaemia/ reperfusion damage, hypertension, hepatitis and cancer.
Tipo:  Article
Idioma:  Inglês
Identificador:  Fernandes, Eduarda; Carvalho, Félix; Silva, Artur; Santos, Clementina; Pinto, Diana; Cavaleiro, José; Bastos, Maria de Lourdes (2002) - 2-Styrylchromones as novel inhibitors of xanthine oxidase. A structure-activity study. ISSN 1475-6366. 17:1, p. 45-48

1475-6366

http://hdl.handle.net/10198/3931
Editor:  Taylor & Francis
Direitos:  open access
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