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Provedor de dados:  Inra
País:  France
Título:  An important step in Listeria lipoprotein research
Autores:  Garcia-del Portillo, F.
Cossart, P.
Data:  2007
Ano:  2007
Palavras-chave:  LIPOPROTEINE
LISTERIA MONOCYTOGENES
VIRULENCE
BACTERIE GRAM-POSITIVE
BACTERIE GRAM-NEGATIVE
BACTERIE PATHOGENE
ADN
SEQUENCE NUCLEOTIDIQUE
ANALYSE PHYLOGENETIQUE
REGULATION
PROTEINE
SURFACE CELLULAIRE
VIRULENCE
TECHNIQUE ANALYTIQUE
BIOCHIMIE
Resumo:  Over the last 10 years, DNA sequences of more than 600 bacterial species have been deposited in databases and are now available to search any gene, motif, or regulatory sequence of interest. Although genome data are instrumental in phylogenetic analysis and in silico design of metabolic and regulatory networks, only a very small fraction of the information has been experimentally validated. A striking example is lipoproteins predicted from genome sequences. Despite the predominance of this class of surface proteins in bacteria (up to 0.5 to 8% of the proteome), very few of these proteins have been identified as lipoproteins by biochemical methods (19). In this issue of the Journal of Bacteriology, Baumgärtner et al. (2) report a systematic analysis of lipoproteins of Listeria monocytogenes, a facultative gram-positive intracellular bacterial pathogen that causes severe infections (listeriosis) in both human and animals. These authors used an L. monocytogenes mutant defective in lipoprotein diacylglyceryl transferase (Lgt), an enzyme involved in lipoprotein processing. Three aspects of their study should be highlighted: (i) new findings concerning the roles of Lgt and lipoprotein-specific signal peptidase II (Lsp) during lipoprotein processing (22); (ii) the identification of 26 of the 68 lipoproteins predicted in the initial annotation of the L. monocytogenes strain EGD-e genome (7); and (iii) experimental evidence that a few of these lipoproteins are regulated by PrfA, the master virulence regulator of L. monocytogenes (8). Below, we discuss the significance of these findings separately.
Tipo:  Journal Article
Idioma:  Inglês
Identificador:  http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2009594c400a&uri=/notices/prodinra1/2009/11/
Fonte:  Journal of Bacteriology. 2007, 189 (2) : 294-297
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