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Provedor de dados:  Inra
País:  France
Título:  The insect attractant 1-Octen-3-o1 is the natural ligand of bovine odorant-binding protein
Autores:  Ramoni, R.
Vincent, F.
Grolli, S.
Conti, V.
Malosse, C.
Boyer, F.D.
Nagnan-Le Meillour, P.
Spinelli, S.
Cambillau, C.
Tegoni, M.
Data:  2001
Ano:  2001
Palavras-chave:  TECHNIQUE ANALYTIQUE
SPECTROMÉTRIE DE MASSE
CHROMATOGRAPHIE EN PHASE GAZEUSE
STRUCTURE TRIDIMENSIONNELLE
LIGAND FLUORESCENCE SPECTROSCOPY
URINARY PROTEINS
NASAL-MUCOSA
AFFINITIES
MECHANISM
LIPOCALIN
MOSQUITOS
RECEPTOR
Resumo:  Bovine odorant-binding protein (bOBP) is a dimeric lipocalin present in large amounts in the respiratory and olfactory nasal mucosa. The structure of bOBP refined at 2.0-Å resolution revealed an elongated volume of electron density inside each buried cavity, indicating the presence of one (or several) naturally occurring copurified ligand(s) (Tegoni et al. (1996)Nat. Struct. Biol. 3, 863–867; Bianchet et al.(1996) Nat. Struct. Biol. 3, 934–939). In the present work, by combining mass spectrometry, x-ray crystallography (1.8-Å resolution), and fluorescence, it has been unambiguously established that natural bOBP contains the racemic form of 1-octen-3-ol. This volatile substance is a typical component of bovine breath and in general of odorous body emanations of humans and animals. The compound 1-octen-3-ol is also an extremely potent olfactory attractant for many insect species, including some parasite vectors likeAnopheles (Plasmodium) or Glossina(Trypanosoma). For the first time, a function can be assigned to an OBP, with a possible role of bOBP in the ecological relationships between bovine and insect species.
Tipo:  Journal Article
Idioma:  Inglês
Identificador:  http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PUB0200012319094103&uri=/notices/prodinra1/2010/10/

http://www.prodinra.inra.fr/prodinra/pinra/data/2010/10/PUB020001231909410_20101029122149950.pdf
Formato:  application/pdf
Fonte:  Journal of Biological Chemistry. 2001, 276 (10) : 7150-7155
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