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Provedor de dados:  OAK
País:  Japan
Título:  Expression of uterine lipocalin 2 and its receptor during early- to mid-pregnancy period in mares
Autores:  Haneda, Shingo
Nagaoka, Kentaro
Nambo, Yasuo
Kikuchi, Masato
Nakano, Yasuko
Li, Junyou
Matsui, Motozumi
Miyake, Yo-ichi
Imakawa, Kazuhiko
Data:  2017-04
Ano:  2017
Palavras-chave:  Endometrium
Lipocalin 2 (LCN2)
LCN2 receptor (SLC22A17)
Matrix metalloproteinase-9 (MMP9)
Resumo:  From previous cDNA subtraction studies analyzing gene expression in equine endometrium, high lipocalin 2 (LCN2) mRNA expression was found in the gravid endometrium. In the uterus, LCN2 may transport hydrophobic molecules and siderophores with iron, or may form a complex with another protein, however, the expression of uterine LCN2 beyond day 20 of equine pregnancy and its receptor has not been characterized. To study the expression and potential roles of uterine LCN2 from pre-implantation to mid-gestation period, stage-specific endometrial samples were obtained from day 13 (day 0 = ovulation) cyclic and days 13, 19, 25, and 60 to 131 pregnant mares. Expression of LCN2 mRNA increased in day 19 gravid endometrium and was abundant from day 60 onward. The expression of LCN2 mRNA was localized to the glandular epithelium. LCN2 protein was detected in day 25 gravid endometrium and luminal fluid, and the protein was localized to the glandular epithelium and luminal cavity, whereas LCN2 receptor expression was found in luminal and glandular epithelium and trophectoderm throughout the experimental period. The presence of matrix metalloproteinase-9 (MMP9) was also examined because MMP9 is known to form a complex with LCN2. Although MMP9 and LCN2 were both found in luminal fluid from day 25 pregnant uterus, the complex of these proteins was not detected. Localization of the receptor in the trophectoderm suggests that endometrial LCN2 could play a role in carrying small substances from the mother to fetus in the equine species.
Idioma:  Inglês

Editor:  Society for Reproduction and Development
Direitos:  This is an open access article licensed under the terms of the Creative Commons Attribution (by) License. <>

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