| Registro completo |
| Provedor de dados: |
OAK
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| País: |
Japan
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| Título: |
Repeated administrations of concanavalin A induce Th1 to Th2 cytokine shift and tolerance against liver injury in mice
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| Autores: |
Tamaki, Yosui
Yoneda, Masashi
Sato, Keisuke
Yokohama, Shiro
Haneda, Masakazu
Nakamura, Kimihide
中村, 公英
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| Data: |
2006-08
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| Ano: |
2006
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| Palavras-chave: |
Concanavalin A
Tolerance
Cytokine
Liver injury
T cell
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| Resumo: |
The intravenous injection of concanavalin A (Con A) activates T cells and induces cytokine dependent liver injury in mice. However, the effect of repeated administrations of Con A has not been fully investigated. Female BALB/c mice were intravenously injected with Con A (20 mg/kg) or saline once a week for six times. Mice were rechallenged with Con A 17 days after repeated administrations of Con A. Repeated Con A administrations elicited a sustained inhibition of rechallenged-Con A-induced liver injury. Plasma TNF-alpha and IFN-gamma levels after rechallenge of Con A were decreased compared with that of repeated saline treatments. By contrast, plasma IL-4 and IL-10 levels after rechallenge of Con A were increased. In spleen cells prepared from repeated Con A treated mice, the production of TNF-alpha and IFN-gamma 24 h after co-incubation with Con A decreased, and that of IL-4 and IL-10 increased. In naive mice, plasma ALT level after Con A injection was decreased by the transfer of spleen cells prepared from the repeated Con A treated mice. The repeated administrations of Con A elicited Th1 to Th2 cytokine shift and the tolerant state against the Con A-induced liver injury in mice. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
http://www.sciencedirect.com/science/journal/13866346
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| Idioma: |
Inglês
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| Identificador: |
http://ir.obihiro.ac.jp/dspace/handle/10322/61
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| Editor: |
ELSEVIER
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| Formato: |
application/pdf
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