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Provedor de dados:  OMA
País:  Belgium
Título:  Accumulation of trimethoprim, sulfamethoxazole, and <i>N</i>-acetylsulfamethoxazole in fish and shrimp fed medicated <i>Artemia franciscana</i>
Autores:  Chair, M.
Nelis, H.J.
Leger, P.
Sorgeloos, P.
De Leenheer, A.P.
Data:  1996
Ano:  1996
Resumo:  In a previous paper (H.J. Nelis, P. Léger, P. Sorgeloos, and A.P. De Leenheer, Antimicrob. Agents Chemother. 35:2486-2489, 1991) it was reported that two selected antibacterial agents, i.e. trimethoprim and sulfamethoxazole, can be efficiently bioencapsulated in nauplii of the brine shrimp <i><i>Artemia</i> franciscana</i> for administration to fish. This follow-up study showed that larvae of the sea bass and the turbot as well as postlarvae of the white shrimp accumulate the therapeutic agents in high quantities when fed medicated <i>A. franciscana</i>. To monitor their levels as a function of time, the liquid chromatographic method originally developed for the analysis of <i>A. franciscana</i> was modified with respect to chromatography, internal standardization, and sample pretreatment. The levels of trimethoprim ranged from 1 to 7 µg/g (sea bass), 1 to 13µg/g (turbot), and 4 to 38 µg/g (white shrimp). The corresponding values for sulfamethoxazole were 0.3 to 4 µg/g (sea bass), 1 to 42 µg/g (turbot), and 4 to 35µg/g (white shrimp). Only the two fish species, unlike the shrimp, metabolized the latter to <i>N</i>-acetylsulfamethoxazole (concentration range, 1 to 10 µg/g). These data suggest the potential of the bioencapsulation of therapeutic agents in live food as a tool to control infectious diseases in aquaculture. A preliminary challenge test also confirmed the in vivo efficacy of this approach.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Fonte:  %3Ci%3EAntimicrob.+Agents+Chemother.+40%287%29%3C%2Fi%3E%3A+1649-1652
Direitos:  info:eu-repo/semantics/restrictedAccess

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