Sabiia Seb
        Busca avançada

Botão Atualizar

Botão Atualizar

Registro completo
Provedor de dados:  OMA
País:  Belgium
Título:  Drug assimilation in the tissue of European sea bass (<i>Dicentrarchus labrax</i>) fry delivered orally through bioencapsulation
Autores:  Gapasin, R.S.J.
Nelis, H.
Chair, M.
Sorgeloos, P.
Data:  1996
Ano:  1996
Palavras-chave:  Dicentrarchus labrax (Linnaeus
1758) [Bass]
Resumo:  Assimilation levels of the antibacterials trimethoprim (TMP) and sulfamethoxazole (SMX) in sea bass (<i>Dicentrarchus labrax</i>) fry tissue administered orally were investigated. A 1:5 TMP and SMX combination incorporated in oil emulsion (Selco) at 20% and 40% concentrations (w/w) were bioencapsulated in <i>Artemia</i> (Instar II) nauplii. Chemotherapeutics-loaded ('medicated') nauplii were fed to the sea bass fry and drug concentration in the tissue were analysed by high-performance liquid chromatography (HPLC). Fish fed 40% 'medicated' <i>Artemia</i> assimilated significantly higher levels of chemotherapeutics compared with those fed 20% 'medicated' <i>Artemia</i> . Chemotherapeutics given at 40% reached peak levels (19.3 µg TMP/g DW and 23.31 µg SMX/g DW) within 2h while those at 20% peaked (8.74 µg TMP/g DW and 6.73 µg SMX/g DW) after 5h. TWP persisted in the tissues longer (up to 72h) than SMX (12-16h), suggesting a more efficient uptake and retention of the former and/or faster metabolism and elimination of the latter.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Relação:  info:eu-repo/semantics/altIdentifier/wos/A1996UK20900007
Direitos:  info:eu-repo/semantics/restrictedAccess

Empresa Brasileira de Pesquisa Agropecuária - Embrapa
Todos os direitos reservados, conforme Lei n° 9.610
Política de Privacidade
Área restrita

Parque Estação Biológica - PqEB s/n°
Brasília, DF - Brasil - CEP 70770-901
Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC:

Valid HTML 4.01 Transitional