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Provedor de dados:  Acta biol.Colomb.
País:  Colombia
Título:  SCORPION VENOM: NEW PROMISE IN THE TREATMENT OF CANCER
Autores:  GÓMEZ RAVE,Lyz Jenny
MUÑOZ BRAVO,Adriana Ximena
SIERRA CASTRILLO,Jhoalmis
ROMÁN MARÍN,Laura Melisa
CORREDOR PEREIRA,Carlos
Data:  2019-08-01
Ano:  2019
Palavras-chave:  Anti-infective agents
Antineoplastic agents
Arachnida
Molecular biology
Peptides
Resumo:  ABSTRACT Cancer is a public health problem due to its high worldwide morbimortality. Current treatment protocols do not guarantee complete remission, which has prompted to search for new and more effective antitumoral compounds. Several substances exhibiting cytostatic and cytotoxic effects over cancer cells might contribute to the treatment of this pathology. Some studies indicate the presence of such substances in scorpion venom. In this review, we report characteristics of the principal scorpion venom components found in recent literature and their potential activity against tumor cells. There are different toxin groups present in the venom, and it seems that their mode of actions involves ionic channel blocking, disruption of the cell membrane integrity and damage to internal cell organelles. These properties make good prospects for studies on drugs and adjuvants in cancer treatment.
Tipo:  Journal article
Idioma:  Inglês
Identificador:  http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-548X2019000200213
Editor:  Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Biología
Formato:  text/html
Fonte:  Acta Biológica Colombiana v.24 n.2 2019
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