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Provedor de dados:  Acta biol.Colomb.
País:  Colombia
Título:  EXPORT AND TRAFFICKING OF Plasmodium PROTEINS WITHIN THE HOST ERYTHROCYTE
Autores:  WISER,MARK F
Data:  2007-11-01
Ano:  2007
Palavras-chave:  Secretory pathway
SERCA
Protein trafficking
Malaria
Resumo:  The export and trafficking of parasite proteins within the infected erythrocyte is a complex process and not well understood. Export of proteins from the parasite was previously speculated to involve a specialized compartment originally designated as the secondary endoplasmic reticulum of the Apicomplexa, or sERA. The properties of this Plasmodium export compartment are reviewed in regards to more recent observations about the trafficking of Plasmodium proteins within the host erythrocyte. In addition, a calcium ATPase unique to the Apicomplexa and with homology to the sarcoplasmicendoplasmic reticulum calcium ATPase is discussed in the context of this unique export compartment. It is also speculated that the Plasmodium export element, PEXEL, may play a role in targeting proteins to this parasite export compartment. Exported proteins are then proposed to move into the parasitophorous vacuole and those destined for the host erythrocyte are transported to the erythrocyte cytoplasm as soluble proteins. Chaperones probably play a role in escorting parasite proteins to their final destinations and assembly on the erythrocyte membrane
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-548X2007000200001
Editor:  Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Biología
Formato:  text/html
Fonte:  Acta Biológica Colombiana v.12 n.2 2007
Direitos:  info:eu-repo/semantics/openAccess
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