| Registro completo |
| Provedor de dados: |
42
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| País: |
Brazil
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| Título: |
Crude ethanol extract from babassu (Orbignya speciosa): cytotoxicity on tumoral and non-tumoral cell lines
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| Autores: |
Rennó,Magdalena N.
Barbosa,Gleyce M.
Zancan,Patricia
Veiga,Venicio F.
Alviano,Celuta S.
Sola-Penna,Mauro
Menezes,Fábio S.
Holandino,Carla
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| Data: |
2008-09-01
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| Ano: |
2008
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| Palavras-chave: |
Antitumoral agents
Ethanol extract
Orbignya speciosa
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| Resumo: |
Plant-derived substances have been considered as important sources of drugs, including antineoplasic agents. Babassu mesocarp is popularly used in Brazil as a food additive, and in popular medicine against several conditions, such as inflammations, menstrual pains and leukaemia. From babassu Orbignya speciosa (Mart.) Barb. Rodr. [Arecaceae (Palmae)] epicarp/mesocarp, an ethanol extract was prepared and named OSEME, which was tested on the viability,morphology and metabolism of several cell lines, such as the leukaemic cell lines, HL-60, K562 and the latter multidrug resistant counterpart K562-Lucena 1, the human breast cancer cell line MCF-7, the mouse fibroblast cell line 3T3-L1 and fresh human lymphocytes. OSEME promoted a dose-dependent decrease on the viability of all cells. This effect was much more pronounced on the tumoral cell lines than on non-tumoral cells, a phenomenon revealed by the dose of OSEME which promotes half of maximal effect (ID50). The decrease on viability was followed by shrinkage of cells, alteration on their morphology, and a markedly nuclear condensation. Curiously, stimulation of 6-phosphofructokinase activity (6.6-times) was observed on HL-60 cells, treated with OSEME, when compared to control treated with ethanol (vehicle). These results support evidences to suggest OSEME as a promising source of novel antineoplasic agents.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000300008
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| Editor: |
Academia Brasileira de Ciências
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| Relação: |
10.1590/S0001-37652008000300008
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| Formato: |
text/html
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| Fonte: |
Anais da Academia Brasileira de Ciências v.80 n.3 2008
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| Direitos: |
info:eu-repo/semantics/openAccess
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