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Provedor de dados:  Anais da ABC (AABC)
País:  Brazil
Título:  Evaluation of the predisposition and clinical impact of BK virus replication in kidney transplant patients
Autores:  MOURA,ELVIANI B.
PETZHOLD,SILVIA V.
AMARAL,AUGUSTO R.
DEBONI,LUCIANE M.
FRANÇA,PAULO H.C. DE
Data:  2017-05-01
Ano:  2017
Palavras-chave:  BK virus
Nephropathy
Renal transplantation
Viremia
Resumo:  ABSTRACT The BK virus (BKV) produces a subclinical kidney infection in immunocompetent individuals. However, viremia may occur in kidney transplant patients with ongoing immunosuppression. BKV-associated nephropathy (BKVN) has no specific treatment and is a leading cause of organ transplant loss. In this study, we evaluated the predisposition and the clinical impact of BKV replication in kidney transplant patients during post-transplant monitoring in a reference institution in Brazil. Demographic, clinical and laboratory data generated during routine outpatient follow-up were retrospectively collected. BK viremia was investigated using real-time polymerase chain reaction. Of the 553 participants, 7.4% (n = 41) presented BKV replication. Of these, 16 (39%) lost their kidney graft and interstitial nephritis was identified on kidney biopsy in 50% of the cases. Among the evaluated variables, only the use of the immunosuppressant mycophenolate sodium was identified as a risk factor for viremia (OR 7.96; 95% CI 2.35 to 26.98). The graft survival estimate in BKV-positive patients was significantly reduced (24.8% vs. 85.6%) after 10 years of transplantation. We concluded that defining predisposing factors remains an important challenge for the prevention and control of BKV activity following kidney transplantation, especially considering the development of BKVN and its strong effect on graft maintenance.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000200675
Editor:  Academia Brasileira de Ciências
Relação:  10.1590/0001-3765201720160470
Formato:  text/html
Fonte:  Anais da Academia Brasileira de Ciências v.89 n.1 suppl.0 2017
Direitos:  info:eu-repo/semantics/openAccess
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