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Provedor de dados:  Anais da ABC (AABC)
País:  Brazil
Título:  Molecular farming of antimicrobial peptides: available platforms and strategies for improving protein biosynthesis using modified virus vectors
Autores:  LEITE,MICHEL L.
SAMPAIO,KAMILA B.
COSTA,FABRÍCIO F.
FRANCO,OCTÁVIO L.
DIAS,SIMONI C.
CUNHA,NICOLAU B.
Data:  2019-01-01
Ano:  2019
Palavras-chave:  Antimicrobial peptides
Magnifection
Nicotiana benthamiana
Transient expression
Resumo:  Abstract The constant demand for new antibiotic drugs has driven efforts by the scientific community to prospect for peptides with a broad spectrum of action. In this context, antimicrobial peptides (AMPs) have acquired great scientific importance in recent years due to their ability to possess antimicrobial and immunomodulatory activity. In the last two decades, plants have attracted the interest of the scientific community and industry as regards their potential as biofactories of heterologous proteins. One of the most promising approaches is the use of viral vectors to maximize the transient expression of drugs in the leaves of the plant Nicotiana benthamiana. Recently, the MagnifectionTM expression system was launched. This sophisticated commercial platform allows the assembly of the viral particle in leaf cells and the systemic spread of heterologous protein biosynthesis in green tissues caused by Agrobacterium tumefaciens “gene delivery method”. The system also presents increased gene expression levels mediated by potent viral expression machinery. These characteristics allow the mass recovery of heterologous proteins in the leaves of N. benthamiana in 8 to 10 days. This system was highly efficient for the synthesis of different classes of pharmacological proteins and contains enormous potential for the rapid and abundant biosynthesis of AMPs.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000200851
Editor:  Academia Brasileira de Ciências
Relação:  10.1590/0001-3765201820180124
Formato:  text/html
Fonte:  Anais da Academia Brasileira de Ciências v.91 suppl.1 2019
Direitos:  info:eu-repo/semantics/openAccess
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