| Registro completo |
| Provedor de dados: |
45
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| País: |
Brazil
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| Título: |
Reactivity of p53 protein in canine transmissible venereal tumor
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| Autores: |
Moro,J.V.
Tinucci-Costa,M.
Silveira,A.C.T.
Gerardi,D.G.
Alessi,A.C.
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| Data: |
2010-04-01
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| Ano: |
2010
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| Palavras-chave: |
Immunohistochemistry
P53
Oncology
Transmissible venereal tumor
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| Resumo: |
The expression of p53 protein was evaluated in canine transmissible venereal tumor (CTVT), as following: natural occurrence (n=8); resistant to chemotherapy (n=4); and allogeneic transplanted in progression (n=8), stable (n=8), and regression (n=8)stages. The collected specimens were submitted to GM1 immunohistochemical reaction. Results showed a mean percentage of immunomarked cells around 18.6% in CTVT of natural occurrence, 23.8% in CTVT resistant to chemotherapy, 22.9% in allogeneic transplanted CTVT in both progression and stable stages, and 35.8% in transplanted CTVT in regression stage. The results suggest that there is a functional abnormality in p53 gene and its products in the studied tumors; although, it is not possible to correlate the percentage of cells marked by p53 and a prognosis.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000200011
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| Editor: |
Universidade Federal de Minas Gerais, Escola de Veterinária
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| Relação: |
10.1590/S0102-09352010000200011
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| Formato: |
text/html
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| Fonte: |
Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.62 n.2 2010
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| Direitos: |
info:eu-repo/semantics/openAccess
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