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Provedor de dados:  ArchiMer
País:  France
Título:  Detection of griseofulvin in a marine strain of Penicillium waksmanii by ion trap mass spectrometry
Autores:  Petit, Karina
Mondeguer, Florence
Roquebert, M
Biard, J
Pouchus, Y
Data:  2004-07
Ano:  2004
Palavras-chave:  Mass spectrometry ESI IT/MS
Marine fungi
Penicillium waksmanii
Resumo:  A marine strain of Penicillium waksmanii Zaleski was isolated from a sample of seawater from shellfish-farming area in the Loire estuary (France). The in vitro marine culture showed an important antifungal activity. Bioassay-guided fractionation was used to purify the crude extract. Dereplication by electrospray-ion trap/mass spectrometry (ESI-IT/MS) afforded the identification of the antifungal compound, after a semi-purification consisting of two stages. A comparison of the ionic composition between the active and the non-active fractions allowed the detection of a monocharged ion at m/z 353 containing a chlorine atom, which could be attributed to the antifungal griseofulvin [C17H17ClO6+H](+). Multi-stage fragmentation (MSn) confirmed the identity of the m/z 353 ion of the antifungal fraction as griseofulvin. It is the first description of griseofulvin production by a strain of P. waksmanii and the first chemical study of a strain of this species isolated from marine temperate cold water.
Tipo:  Text
Idioma:  Inglês

Editor:  Elsevier
Formato:  application/pdf
Fonte:  Journal of Microbiological Methods (0167-7012) (Elsevier), 2004-07 , Vol. 58 , N. 1 , P. 59-65
Direitos:  2004 Elsevier B.V. All rights reserved

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