Sabiia Seb
PortuguêsEspañolEnglish
Embrapa
        Busca avançada

Botão Atualizar


Botão Atualizar

Registro completo
Provedor de dados:  ArchiMer
País:  France
Título:  Structural insights into a new homodimeric self-activated GTPase family
Autores:  Gras, S
Chaumont, V
Fernandez, B
Carpentier, P
Charrier Savournin, F
Schmitt, Sophie
Pineau, C
Flament, Didier
Hecker, A
Forterre, P
Armengaud, J
Housset, D
Data:  2007-06
Ano:  2007
Palavras-chave:  Structure
SIMIBI
Replication
GTPase
Crystal
Resumo:  The human XAB1/ MBDin GTPase and its close homologues form one of the ten phylogenetically distinct families of the SIMIBI ( after signal recognition particle, MinD and BioD) class of phosphate- binding loop NTPases. The genomic context and the partners identified for the archaeal and eukaryotic homologues indicate that they are involved in genome maintenance - DNA repair or replication. The crystal structure of PAB0955 from Pyrococcus abyssi shows that, unlike other SIMIBI class G proteins, these highly conserved GTPases are homodimeric, regardless of the presence of nucleotides. The nucleotide- binding site of PAB0955 is rather rigid and its conformation is closest to that of the activated SRP G domain. One insertion to the G domain bears a strictly conserved GPN motif, which is part of the catalytic site of the other monomer and stabilizes the phosphate ion formed. Owing to this unique functional feature, we propose to call this family as GPN- loop GTPase.
Tipo:  Text
Idioma:  Inglês
Identificador:  http://archimer.ifremer.fr/doc/2007/publication-4724.pdf

DOI:10.1038/sj.embor.7400958
Editor:  Nature
Relação:  http://archimer.ifremer.fr/doc/00000/4724/
Formato:  application/pdf
Fonte:  Embo reports (1469-221X) (Nature), 2007-06 , Vol. 8 , N. 6 , P. 569-575
Direitos:  2008 European Molecular Biology Organization, Nature publishing group
Fechar
 

Empresa Brasileira de Pesquisa Agropecuária - Embrapa
Todos os direitos reservados, conforme Lei n° 9.610
Política de Privacidade
Área restrita

Embrapa
Parque Estação Biológica - PqEB s/n°
Brasília, DF - Brasil - CEP 70770-901
Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco

Valid HTML 4.01 Transitional