| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Retracing the path of planar cell polarity
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| Autores: |
Schenkelaars, Quentin
Fierro-constain, Laura
Renard, Emmanuelle
Borchiellini, Carole
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| Data: |
2016-04
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| Ano: |
2016
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| Palavras-chave: |
Planar cell polarity
Van Gogh
Multigene families
Porifera
Placozoa
Ctenophora
Wnt signaling
Metazoan phylogeny
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| Resumo: |
Background: The Planar Cell Polarity pathway (PCP) has been described as the main feature involved in patterning cell orientation in bilaterian tissues. Recently, a similar phenomenon was revealed in cnidarians, in which the inhibition of this pathway results in the absence of cilia orientation in larvae, consequently proving the functional conservation of PCP signaling between Cnidaria and Bilateria. Nevertheless, despite the growing accumulation of databases concerning basal lineages of metazoans, very few information concerning the existence of PCP components have been gathered outside of Bilateria and Cnidaria. Thus, the origin of this module or its prevalence in early emerging metazoans has yet to be elucidated. Results: The present study addresses this question by investigating the genomes and transcriptomes from all poriferan lineages in addition to Trichoplax (Placozoa) and Mnemiopsis (Ctenophora) genomes for the presence of the core components of this pathway. Our results confirm that several PCP components are metazoan innovations. In addition, we show that all members of the PCP pathway, including a bona fide Strabismus ortholog (Van gogh), are retrieved only in one sponge lineage (Homoscleromorpha) out of four. This highly suggests that the full PCP pathway dates back at least to the emergence of homoscleromorph sponges. Consequently, several secondary gene losses would have occurred in the three other poriferan lineages including Amphimedon queenslandica (Demospongiae). Several proteins were not retrieved either in placozoans or ctenophores leading us to discuss the difficulties to predict orthologous proteins in basally branching animals. Finally, we reveal how the study of multigene families may be helpful to unravel the relationships at the base of the metazoan tree. Conclusion: The PCP pathway antedates the radiation of Porifera and may have arisen in the last common ancestor of animals. Oscarella species now appear as key organisms to understand the ancestral function of PCP signaling and its potential links with Wnt pathways.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
https://archimer.ifremer.fr/doc/00371/48250/48685.pdf
https://archimer.ifremer.fr/doc/00371/48250/48686.pdf
https://archimer.ifremer.fr/doc/00371/48250/48687.pdf
DOI:10.1186/s12862-016-0641-0
https://archimer.ifremer.fr/doc/00371/48250/
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| Editor: |
Biomed Central Ltd
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| Formato: |
application/pdf
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| Fonte: |
Bmc Evolutionary Biology (1471-2148) (Biomed Central Ltd), 2016-04 , Vol. 16 , N. 69 , P. 1-13
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| Direitos: |
2016 Schenkelaars et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver...
info:eu-repo/semantics/openAccess
restricted use
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